i Themba Labs





Introduction
Earth entered into an agreement with iThemba Labs, the University of the Western Cape, Cape University and Stellenbosch University. The ceremonial signing of the Memorandum of Understanding will take place on 15 March 2007 at the iThema Labs in Cape Town.

iThemalab developed unique proton as well as neutron beam radiation as curative treatment against cancer tumors. With an aiming accuracy of 0.5 mm, this technology enables treatment of complicated tumor of the brain and pituitary. Aiming is achieved with 9 cameras place positioning and skull fixation with full custom made face masks.



Laboratory for accelerator based sciences
The iThemba Laboratory for Accelerator-Based Sciences is a group of multi-disciplinary research laboratories administered by the National Research Foundation. Based at two sites in Western Cape and Gauteng, these provide facilities for:

  • Basic and applied research using particle beams
  • Particle radiotherapy for the treatment of cancer
  • The supply of accelerator-produced
    radioactive isotopes for nuclear medicine and research

Activities are based around a number of sub-atomic particle accelerators. The largest of these, a k-200 separated sector cyclotron, accelerates protons to energies of 200MeV, and heavier particles to much higher energies. Smaller accelerators at the Western Cape site are two injector cyclotrons, one providing intense beams of light ions, and the other, beams of polarized light ions or heavy ions, and a 6MV Van de Graaff electrostatic accelerator. Accelerators at the Gauteng site include a 6MV tandem Van de Graaff electrostatic accelerator and two low energy electrostatic accelerators for ion implantation and other surface science studies. iThemba LABS brings together scientists working in the physical, medical and biological sciences. The facilities provide opportunities for modern research, advanced education, the treatment of cancers, and the production of unique radioisotopes.

iThemba LABS focuses on providing scientifically and medically useful radiation through the acceleration of charged particles using the  cyclotrons, the electrostatic accelerators and other appropriate technologies. iThemba LABS is to be the primary center of expertise in radiation medicine and nuclear science and technologies to advance the knowledge and health of the people of Africa.

The basic skills and facilities at iThemba LABS are in the applied and pure sub-atomic sciences and associated technologies. Worldwide, these basic sciences are growing strongly. The applications of these sciences to technology are also growing rapidly indeed. For example, there is an international scarcity of radioisotopes creating a market into which iThemba LABS' products have had speedy access due to their quality and innovative nature. There is also a shortage of the skills and human resources required to satisfy these growing markets and economic requirements. The training programmes at iThemba LABS are essential both for transforming the South African science and technology (S&T) workforce and for growing the skills required to build a successful economy in which there are sufficient resources to eradicate poverty.

As a national research facility working within the National System of Innovation it is the intention of iThemba LABS to achieve the following strategic objectives:

  • Grow the research facilities to increase training, human resource development, international collaborations (especially with Africa) and the Science and Technology profile of South Africa.
  • To spin off economic units that are self-sustaining and benefit from the skills, sciences and technologies developed and available at iThemba LABS. To this end the following should be achieved:
  • Realize the Major Radiation Medical Centre (MRMC) project;
  • Grow radio nuclide production into a substantial business;
  • Substantially improve training and research outputs;
  • Strengthen beneficial collaborations with the higher education sector;
  • Forge closer ties with South African and African S&T institutions;
  • Position to have the skills and capacity to respond to the sub- atomic technology needs of 2005- 2010. For example, in this period fourth-generation synchrotron radiation sources and accelerator-based free electron lasers may well be needed by the African S&T community to impact advances in chemistry and biology;
  • Quickly expand the IT/electronics instrumentation capacity at iThemba LABS. The current capacity barely meets basic needs. Skills and capacity in these disciplines are vital to the national interest;
  • Acquire the capacity to technically and scientifically service university research groups that wish to use international facilities such as CERN, ILL, ESRS, SESEME, CEBAF Spring 8, and so forth. This servicing activity is one of the key functions of national research laboratories internationally;
  • Substantially expand the number of post-doctoral fellowship and research assistant posts to increase opportunities for young South Africans to establish international research reputations.



Behandeling met protonen
Behandeling met protonen is een effectieve manier om een optimale tumordosis te combineren met beperkte dosis aan omliggende weefsels. Proton therapy wordt al jaren succesvol toegepast bij o.a. chordomen en chondrosarcomen en met het op grotere schaal beschikbaar komen van faciliteiten ook voor andere indicaties (o.a. bepaalde KNO tumoren, hersentumoren) ingezet. Eén van de belangrijkste knelpunten zijn de immense kosten die er mee verbonden zijn. Er wordt gewerkt aan nieuwe, goedkopere technieken om protonentherapie toe te kunnen passen. In hoeverre het voorstel in Zuid-Afrika levensvatbaar is kan ik vanaf hier niet beoordelen, maar toepassing van proton therapy zal naar ik verwacht in de komende 10 jaar aan toepassingsgebied winnen. In de bijlage nog wat oude plannen en een oude kostenraming van deze groep.

Bob Pinedo
                                                                                                                               



 


Precision fixation mask
 

Proton beam
 



neutron beam

 

aiming with 0.5 mm accuracy of the
beam through 9 cameras

 

RATIONALE
Neutrons and protons are both nuclear particles of approximately the same mass. However, the fact that neutrons are uncharged and protons are charged particles results in their having vastly different physical properties and biological effects. Using conventional photon radiation as the standard, the dose distributions of fast neutrons are very similar, but their biological effects offer advantages for the treatment of certain types of tumours, while the advantages of protons lie in their physical dose distributions.

Many large tumours have central cores, which lack oxygen because the blood supply has been reduced by the proliferating tumour cells. Other tumours are slow-growing and the cells spend a relatively short time in the dividing phase of the cell cycle, where they are most sensitive to radiation. These tumours are resistant to conventional photon radiation but are far less resistant to neutron irradiation, which therefore in principle has a better chance of effecting a cure. Examples of tumours that are effectively treated by neutrons include salivary gland tumours, large breast tumours and certain tumours of other soft tissues. However, because radiation causes damage to the normal tissue in front of a deep-seated tumour, a so-called isocentric beam delivery system (one which rotates about the patient) is essential so that the patient can be irradiated from several different angles. This concentrates the dose at the tumour and limits the dose to normal tissue.

High energy protons are particularly suitable for treating cancer or other (benign) abnormalities near sensitive structures such as the optic nerve, spinal cord, kidneys, etc., where other forms of radiation would do too much damage to healthy tissue. This feature results from the fact that protons can be steered and focused very accurately and can also be given exactly the right energy to stop at any particular point within the body, thus completely protecting any organs beyond this range. They also allow better protection of normal tissue, situated in front and at the sides of the target, than other types of radiation. This allows the application of higher doses to a tumour which means a better chance of cure. The high precision required in proton therapy demands the ability to accurately set the patient up in the proton beam. Although not as important as in the case of neutron therapy, the ability to irradiate the patient from different angles is desirable.


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